健康小天使 发表于 2022-8-8 10:11:33

吃降压药的人，千万当心一种水果


            <section style="box-sizing: border-box;font-size: 16px;margin-bottom: 0px;" data-mpa-powered-by="yiban.io"><section style="text-align: center;justify-content: center;box-sizing: border-box;" powered-by="xiumi.us"><section style="display: inline-block;width: 92%;vertical-align: top;height: auto;box-sizing: border-box;"><section style="margin-right: 0%;margin-left: 0%;box-sizing: border-box;" powered-by="xiumi.us"><section style="max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;"><br></section></section></section></section><section style="text-align: center;justify-content: center;box-sizing: border-box;" powered-by="xiumi.us"><section style="display: inline-block;width: 92%;vertical-align: top;height: auto;box-sizing: border-box;"><section style="margin-right: 0%;margin-left: 0%;box-sizing: border-box;" powered-by="xiumi.us"><section style="text-align: justify;color: rgb(102, 102, 102);line-height: 2;letter-spacing: 0px;box-sizing: border-box;"><p style="white-space: normal;box-sizing: border-box;"><span style="letter-spacing: 0px;box-sizing: border-box;">前段时间，西柚在微博上火了一把。</span></p><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p><p style="white-space: normal;box-sizing: border-box;">就是下图这个玩意儿，也叫「葡萄柚」。</p></section></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="margin-right: 0%;margin-left: 0%;box-sizing: border-box;" powered-by="xiumi.us"><section style="max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;width: 100%;height: auto;box-sizing: border-box;"><br><br></section></section><section style="margin-top: 15px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;" powered-by="xiumi.us"><section style="font-size: 12px;color: rgb(206, 206, 206);line-height: 1.9;letter-spacing: 0.7px;padding-right: 10px;padding-left: 10px;box-sizing: border-box;"><p style="box-sizing: border-box;">图片来源：站酷海洛</p></section></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="margin-right: 0%;margin-left: 0%;box-sizing: border-box;" powered-by="xiumi.us"><section style="text-align: justify;color: rgb(102, 102, 102);line-height: 2;letter-spacing: 0px;box-sizing: border-box;"><p style="white-space: normal;box-sizing: border-box;"><span style="letter-spacing: 0px;box-sizing: border-box;">倒不是因为西柚有多好吃（虽然确实挺好吃的），而是因为——作为一种常见的水果，西柚和药同服，居然可能导致危险。</span></p></section></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="margin: 5px 0%;box-sizing: border-box;" powered-by="xiumi.us"><section style="font-size: 14px;color: rgb(102, 102, 102);line-height: 1.8;padding-right: 5px;padding-left: 5px;letter-spacing: 0.4px;box-sizing: border-box;"><p style="box-sizing: border-box;">&#128072;左滑查看大图</p></section></section><section style="display: inline-block;width: 100%;vertical-align: top;overflow-x: auto;box-sizing: border-box;" powered-by="xiumi.us"><section style="overflow: hidden;width: 500%;max-width: 500% !important;box-sizing: border-box;"><section style="display: inline-block;vertical-align: top;width: 20%;box-sizing: border-box;" powered-by="xiumi.us"><section style="margin-right: 0%;margin-left: 0%;box-sizing: border-box;"><section style="max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;"><br><br></section></section></section><section style="display: inline-block;vertical-align: top;width: 20%;box-sizing: border-box;" powered-by="xiumi.us"><section style="margin-right: 0%;margin-left: 0%;box-sizing: border-box;"><section style="max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;"><br><br></section></section></section><section style="display: inline-block;vertical-align: top;width: 20%;box-sizing: border-box;" powered-by="xiumi.us"><section style="margin-top: 10px;margin-bottom: 10px;width: 100%;box-sizing: border-box;"><section style="max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;width: 100%;box-sizing: border-box;"><br><br></section></section></section><section style="display: inline-block;vertical-align: top;width: 20%;box-sizing: border-box;" powered-by="xiumi.us"><section style="margin-top: 10px;margin-bottom: 10px;width: 100%;box-sizing: border-box;"><section style="max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;width: 100%;box-sizing: border-box;"><br><br></section></section></section><section style="display: inline-block;vertical-align: middle;width: 20%;box-sizing: border-box;" powered-by="xiumi.us"><section style="margin-right: 0%;margin-left: 0%;box-sizing: border-box;"><section style="max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;box-sizing: border-box;"><br><br></section></section></section></section></section><section style="margin-top: 15px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;" powered-by="xiumi.us"><section style="font-size: 12px;color: rgb(206, 206, 206);line-height: 1.9;letter-spacing: 0.7px;padding-right: 10px;padding-left: 10px;box-sizing: border-box;"><p style="box-sizing: border-box;">图片来源：微博截图</p></section></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="margin-right: 0%;margin-left: 0%;box-sizing: border-box;" powered-by="xiumi.us"><section style="text-align: justify;color: rgb(102, 102, 102);line-height: 2;letter-spacing: 0px;box-sizing: border-box;"><p style="white-space: normal;box-sizing: border-box;"><span style="letter-spacing: 0px;box-sizing: border-box;">或许对大多数人来说，需要吃药的时候很少。但对于一些慢性病患者来说，尤其是高血压患者，降压药最忌讳的就是吃吃停停，需要每天坚持吃药。</span><br style="box-sizing: border-box;"></p><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p><p style="white-space: normal;box-sizing: border-box;">正值西柚上市的季节，如果你在吃药，这种水果别随便买。</p></section></section></section></section><section style="box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="margin-right: 0%;margin-bottom: 5px;margin-left: 0%;text-align: center;box-sizing: border-box;" powered-by="xiumi.us"><section style="display: inline-block;vertical-align: top;box-sizing: border-box;"><section style="margin-bottom: -6px;line-height: 1;padding-right: 5px;padding-left: 5px;font-size: 18px;letter-spacing: 1px;color: rgb(0, 0, 0);text-align: right;box-sizing: border-box;"><p style="box-sizing: border-box;"><strong style="box-sizing: border-box;">吃降压药又吃西柚</strong></p></section><section style="width: 100%;height: 10px;background-color: rgba(132, 107, 255, 0.4);box-sizing: border-box;"><section><svg viewBox="0 0 1 1" style="float:left;line-height:0;width:0;vertical-align:top;"></svg></section></section></section></section><section style="margin-right: 0%;margin-bottom: 5px;margin-left: 0%;text-align: center;box-sizing: border-box;" powered-by="xiumi.us"><section style="display: inline-block;vertical-align: top;box-sizing: border-box;"><section style="margin-bottom: -6px;line-height: 1;padding-right: 5px;padding-left: 5px;font-size: 18px;letter-spacing: 1px;color: rgb(0, 0, 0);text-align: right;box-sizing: border-box;"><p style="box-sizing: border-box;"><strong style="box-sizing: border-box;">可能导致危险</strong></p></section><section style="width: 100%;height: 10px;background-color: rgba(132, 107, 255, 0.4);box-sizing: border-box;"><section><svg viewBox="0 0 1 1" style="float:left;line-height:0;width:0;vertical-align:top;"></svg></section></section></section></section><section style="box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="text-align: center;justify-content: center;box-sizing: border-box;" powered-by="xiumi.us"><section style="display: inline-block;width: 92%;vertical-align: top;height: auto;box-sizing: border-box;"><section style="text-align: justify;color: rgb(102, 102, 102);line-height: 2;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><span style="color: rgb(0, 0, 0);box-sizing: border-box;"><strong style="box-sizing: border-box;">西柚之所以如此特别，是因为含一种叫做</strong></span><span style="color: rgb(0, 0, 0);box-sizing: border-box;"><strong style="box-sizing: border-box;">「呋喃香豆素 (furanocoumarins) 」</strong></span><strong style="color: rgb(0, 0, 0);box-sizing: border-box;">的成分。</strong></p><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p><p style="white-space: normal;box-sizing: border-box;">呋喃香豆素，原本是西柚为了自我保护、抵御昆虫啃食而进化出的物质。然而，它的杀伤力可不止这点，虽然不至于伤害人体，但会抑制肝脏中 CYP3A4 酶的活性。</p><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p><p style="white-space: normal;box-sizing: border-box;">药物之所以经由肝脏代谢，正是肝脏中的酶在发挥作用，CYP3A4 酶就是其中一种。</p><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p><p style="white-space: normal;box-sizing: border-box;">我们可以把吃进去的药想象成一堆货物，CYP3A4 酶就像是货车，逐渐把货物运输到体外，避免货物在体内大量滞留。</p></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="margin-right: 0%;margin-left: 0%;box-sizing: border-box;" powered-by="xiumi.us"><section style="vertical-align: middle;display: inline-block;line-height: 0;width: 100%;height: auto;box-sizing: border-box;"><br><br></section></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="text-align: justify;color: rgb(102, 102, 102);line-height: 2;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;">呋喃香豆素抑制 CYP3A4 酶的活性，意味着可用的货车变少，积攒在体内的货物就多了。<br style="box-sizing: border-box;"></p></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="margin-right: 0%;margin-left: 0%;box-sizing: border-box;" powered-by="xiumi.us"><section style="max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;width: 100%;height: auto;box-sizing: border-box;"><br><br></section></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="text-align: justify;color: rgb(102, 102, 102);line-height: 2;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><span style="color: rgb(0, 0, 0);box-sizing: border-box;"><strong style="box-sizing: border-box;">简单来说就是：吃药的同时又吃了西柚，相当于无形中增加了药物剂量。</strong></span></p><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p><p style="white-space: normal;box-sizing: border-box;">而增加降压药的药物剂量，容易引起低血压，这可能是危险的——轻的话头晕心慌乏力，严重可能晕倒甚至休克。</p><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p><p style="white-space: normal;box-sizing: border-box;">有报道的案例发生在日本：一个人吃硝苯地平的同时，喝了大概 500mL 的西柚汁，结果血压迅速下降导致了危险。</p><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p><p style="white-space: normal;box-sizing: border-box;">虽说不是所有降压药都会受影响，但像硝苯地平、氯沙坦这些最常见的降压药，是会受到西柚影响的：</p></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="margin-right: 0%;margin-left: 0%;box-sizing: border-box;" powered-by="xiumi.us"><section style="max-width: 100%;vertical-align: middle;display: inline-block;line-height: 0;width: 100%;height: auto;box-sizing: border-box;"><br><br></section></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="text-align: justify;color: rgb(102, 102, 102);line-height: 2;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;">正因如此，很多降压药的说明书上都会标注：用药期间不得吃西柚或者喝西柚汁（虽然大多数人并不看）。</p></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="margin-right: 0%;margin-left: 0%;box-sizing: border-box;" powered-by="xiumi.us"><section style="vertical-align: middle;display: inline-block;line-height: 0;width: 100%;border-style: solid;border-width: 1px;border-color: rgb(239, 241, 236);box-shadow: rgba(240, 214, 19, 0) 0px 0px 0px;height: auto;box-sizing: border-box;"><br><br></section></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="text-align: justify;color: rgb(102, 102, 102);line-height: 2;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;">事实上，会受到影响的不只是降压药……</p></section></section></section><section style="box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="margin-right: 0%;margin-bottom: 5px;margin-left: 0%;text-align: center;box-sizing: border-box;" powered-by="xiumi.us"><section style="display: inline-block;vertical-align: top;box-sizing: border-box;"><section style="margin-bottom: -6px;line-height: 1;padding-right: 5px;padding-left: 5px;font-size: 18px;letter-spacing: 1px;color: rgb(0, 0, 0);text-align: right;box-sizing: border-box;"><p style="box-sizing: border-box;"><strong style="box-sizing: border-box;">但凡是在吃药</strong></p></section><section style="width: 100%;height: 10px;background-color: rgba(132, 107, 255, 0.4);box-sizing: border-box;"><section><svg viewBox="0 0 1 1" style="float:left;line-height:0;width:0;vertical-align:top;"></svg></section></section></section></section><section style="margin-right: 0%;margin-bottom: 5px;margin-left: 0%;text-align: center;box-sizing: border-box;" powered-by="xiumi.us"><section style="display: inline-block;vertical-align: top;box-sizing: border-box;"><section style="margin-bottom: -6px;line-height: 1;padding-right: 5px;padding-left: 5px;font-size: 18px;letter-spacing: 1px;color: rgb(0, 0, 0);text-align: right;box-sizing: border-box;"><p style="box-sizing: border-box;"><strong style="box-sizing: border-box;">就最好别吃西柚</strong></p></section><section style="width: 100%;height: 10px;background-color: rgba(132, 107, 255, 0.4);box-sizing: border-box;"><section><svg viewBox="0 0 1 1" style="float:left;line-height:0;width:0;vertical-align:top;"></svg></section></section></section></section><section style="box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="text-align: center;justify-content: center;box-sizing: border-box;" powered-by="xiumi.us"><section style="display: inline-block;width: 92%;vertical-align: top;height: auto;box-sizing: border-box;"><section style="margin-right: 0%;margin-left: 0%;box-sizing: border-box;" powered-by="xiumi.us"><section style="text-align: justify;color: rgb(84, 84, 84);line-height: 2;letter-spacing: 0px;box-sizing: border-box;"><p style="white-space: normal;box-sizing: border-box;">上面说过，西柚里的呋喃香豆素，会抑制肝脏中 CYP3A4 酶的活性。</p><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p><p style="white-space: normal;box-sizing: border-box;"><strong style="box-sizing: border-box;"><span style="color: rgb(0, 0, 0);box-sizing: border-box;">然而，这种酶参与了现今使用近半数药物的代谢。</span></strong>这其中既包括一些特殊患者用到的安眠药、抗癌药，也包括很多人常吃的抗生素、止痛药、避孕药。</p><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p><p style="white-space: normal;box-sizing: border-box;">不同的药物受到的影响不尽相同。但总体来说，呋喃香豆素可以使药物以 2～10 倍的量进入血液（1000 倍还是夸张了，其实不至于）。</p><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p><p style="white-space: normal;box-sizing: border-box;">有研究表明：</p><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section></section><section style="margin: 10px 0% 8px;box-sizing: border-box;" powered-by="xiumi.us"><section style="display: inline-block;vertical-align: top;border-left: 3px solid rgba(132, 107, 255, 0.4);border-bottom-left-radius: 0px;padding-left: 8px;width: 100%;height: auto;box-sizing: border-box;"><section style="text-align: justify;color: rgb(102, 102, 102);line-height: 2;letter-spacing: 0px;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;">吃降血脂药（辛伐他汀类）的同时喝 1 杯西柚汁，血药浓度会提高 260%，增加横纹肌溶解症的风险。</p></section></section></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="margin: 10px 0% 8px;box-sizing: border-box;" powered-by="xiumi.us"><section style="display: inline-block;vertical-align: top;border-left: 3px solid rgba(132, 107, 255, 0.4);border-bottom-left-radius: 0px;padding-left: 8px;width: 100%;height: auto;box-sizing: border-box;"><section style="text-align: justify;color: rgb(102, 102, 102);line-height: 2;letter-spacing: 0px;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;">在服用抗心律失常药（胺碘酮）的同时喝 300mL 的西柚汁，与不喝西柚汁的人相比，血药浓度增加了 84%。尽管只有少数抗心律失常药会受到西柚汁影响，但一旦被影响，后果可能是严重的。</p></section></section></section><section style="margin-right: 0%;margin-left: 0%;box-sizing: border-box;" powered-by="xiumi.us"><section style="text-align: justify;color: rgb(84, 84, 84);line-height: 2;letter-spacing: 0px;box-sizing: border-box;"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p><p style="white-space: normal;box-sizing: border-box;"><strong style="box-sizing: border-box;"><span style="color: rgb(0, 0, 0);box-sizing: border-box;">目前已知的，有超过 85 种药物会受到西柚的影响，并且其中大概有一半可能导致严重的不良反应。</span></strong></p><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p><p style="white-space: normal;box-sizing: border-box;">但药物种类实在太多了，很难找到会受西柚影响的完整药物名单。我们在这里列出了一些高风险的名单：</p></section></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="margin-right: 0%;margin-left: 0%;box-sizing: border-box;" powered-by="xiumi.us"><section style="vertical-align: middle;display: inline-block;line-height: 0;width: 100%;height: auto;box-sizing: border-box;"><br><br></section></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="margin-right: 0%;margin-left: 0%;box-sizing: border-box;" powered-by="xiumi.us"><section style="text-align: justify;color: rgb(84, 84, 84);line-height: 2;letter-spacing: 0px;box-sizing: border-box;"><p style="white-space: normal;box-sizing: border-box;"><span style="letter-spacing: 0px;box-sizing: border-box;">名单并不全面，所以最稳妥的建议还是：<strong style="box-sizing: border-box;"><span style="letter-spacing: 0px;color: rgb(0, 0, 0);box-sizing: border-box;">但凡是在吃药，尤其是极高风险的药物，就最好别吃西柚。</span></strong></span><strong style="color: rgb(0, 0, 0);letter-spacing: 0px;box-sizing: border-box;"></strong></p><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p><p style="white-space: normal;box-sizing: border-box;">如果你还是放不下西柚，那至少确保两件事：咨询专业医生或药师，以及认真看了药品说明书（通常在药物相互作用和注意事项部分）。</p></section></section></section></section><section style="box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="margin-right: 0%;margin-bottom: 5px;margin-left: 0%;text-align: center;box-sizing: border-box;" powered-by="xiumi.us"><section style="display: inline-block;vertical-align: top;box-sizing: border-box;"><section style="margin-bottom: -6px;line-height: 1;padding-right: 5px;padding-left: 5px;font-size: 18px;letter-spacing: 1px;color: rgb(0, 0, 0);text-align: right;box-sizing: border-box;"><p style="box-sizing: border-box;"><strong style="box-sizing: border-box;">一些未解答的疑问</strong></p></section><section style="width: 100%;height: 10px;background-color: rgba(132, 107, 255, 0.4);box-sizing: border-box;"><section><svg viewBox="0 0 1 1" style="float:left;line-height:0;width:0;vertical-align:top;"></svg></section></section></section></section><section style="box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="text-align: center;justify-content: center;box-sizing: border-box;" powered-by="xiumi.us"><section style="display: inline-block;width: 92%;vertical-align: top;height: auto;box-sizing: border-box;"><section style="margin-right: 0%;margin-left: 0%;box-sizing: border-box;" powered-by="xiumi.us"><section style="text-align: justify;color: rgb(84, 84, 84);line-height: 2;letter-spacing: 0px;box-sizing: border-box;"><p style="white-space: normal;box-sizing: border-box;"><span style="color: rgb(102, 102, 102);box-sizing: border-box;">说了这么多，或许还有人想问：那少吃一点可以吗？隔几个小时吃可以吗？</span></p><p style="white-space: normal;box-sizing: border-box;"><br></p><p style="white-space: normal;box-sizing: border-box;"><span style="color: rgb(102, 102, 102);box-sizing: border-box;">那不妨接着往下看：</span></p><p style="white-space: normal;box-sizing: border-box;"><br></p><p style="white-space: normal;box-sizing: border-box;"><strong style="box-sizing: border-box;"><span style="color: rgb(0, 0, 0);box-sizing: border-box;">➊&nbsp; 吃药的时候少吃点西柚，可以吗？</span></strong></p><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p><p style="white-space: normal;box-sizing: border-box;">一整个西柚或 200 mL 的西柚汁，就足以导致全身血药浓度增加和随后的不良反应。</p><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p><p style="white-space: normal;box-sizing: border-box;">一两瓣或许可以，但没必要去冒这个险～</p><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p><p style="white-space: normal;box-sizing: border-box;"><strong style="box-sizing: border-box;"><span style="color: rgb(0, 0, 0);box-sizing: border-box;">➋&nbsp;药和西柚隔几个小时吃，可以吗？</span></strong></p><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p><p style="white-space: normal;box-sizing: border-box;">不可以。隔几个小时吃，并不会降低潜在风险。</p><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p><p style="white-space: normal;box-sizing: border-box;">西柚对 CYP3A4 酶的影响是不可逆的，虽说存在个体差异，但有文献显示：吃了西柚或喝了西柚汁之后，酶活性可能需要长达 72 小时才能恢复。</p><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p><p style="white-space: normal;box-sizing: border-box;">所以说，不光是吃药时不能吃西柚，如果西柚会影响你正在吃的药，整个用药期间都不建议你吃西柚。</p><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p><p style="white-space: normal;box-sizing: border-box;">实在想吃，间隔 3 天以上吧。</p><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p><p style="white-space: normal;box-sizing: border-box;"><strong style="box-sizing: border-box;"><span style="color: rgb(0, 0, 0);box-sizing: border-box;">➌ 不吃西柚，吃普通柚子可以吗？</span></strong></p><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p><p style="white-space: normal;box-sizing: border-box;">稳妥起见，最好不。</p><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p><p style="white-space: normal;box-sizing: border-box;">橙子、青柠和柚子等柑橘类水果，其实都有呋喃香豆素，不过含量通常都比西柚低，危险性也相对小一些，目前不太有药物和柚子、橘子同吃出现危险的案例。</p><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p><p style="white-space: normal;box-sizing: border-box;">但品种不同，呋喃香豆素的含量也有很大波动，生活中也没有办法快速知道含量。如果实在担心，那尽量少吃或不要同时吃。</p><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p><p style="white-space: normal;box-sizing: border-box;">西柚好吃，但吃药的话还是忍忍吧。</p><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p><p style="white-space: normal;box-sizing: border-box;">世界上还有西瓜&#127817;、哈密瓜&#127816;、草莓&#127827;、芒果&#129389;、葡萄&#127815;、圣女果&#127813;……各种又香又甜还无害的水果，等着进到你嘴里～</p></section></section></section></section><section style="text-align: center;justify-content: center;box-sizing: border-box;" powered-by="xiumi.us"><section style="display: inline-block;width: 92%;vertical-align: top;height: auto;box-sizing: border-box;"><section style="display: inline-block;width: 100%;vertical-align: top;box-sizing: border-box;" powered-by="xiumi.us"><section style="justify-content: center;margin-top: 8px;margin-right: 0%;margin-left: 0%;box-sizing: border-box;" powered-by="xiumi.us"><section style="display: inline-block;width: 100%;vertical-align: top;height: auto;box-sizing: border-box;"><section style="box-sizing: border-box;" powered-by="xiumi.us"><section style="margin-right: 0%;margin-left: 0%;text-align: left;justify-content: flex-start;display: flex;flex-flow: row nowrap;box-sizing: border-box;"><section style="display: inline-block;vertical-align: middle;width: auto;flex: 100 100 0%;height: auto;align-self: center;box-sizing: border-box;"><section style="margin-right: 0%;margin-left: 0%;box-sizing: border-box;" powered-by="xiumi.us"><section style="text-align: justify;color: rgb(153, 153, 153);line-height: 1.6;font-size: 13px;box-sizing: border-box;"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section></section></section></section></section></section></section></section></section></section><section style="text-align: center;justify-content: center;box-sizing: border-box;" powered-by="xiumi.us"><section style="display: inline-block;width: 92%;vertical-align: top;height: auto;box-sizing: border-box;"><p><br></p></section></section><section style="box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section><section style="text-align: center;justify-content: center;box-sizing: border-box;" powered-by="xiumi.us"><section style="display: inline-block;width: 92%;vertical-align: top;height: auto;box-sizing: border-box;"><section style="display: inline-block;width: 100%;vertical-align: top;box-sizing: border-box;" powered-by="xiumi.us"><section style="margin-right: 0%;margin-bottom: 2px;margin-left: 0%;box-sizing: border-box;" powered-by="xiumi.us"><section style="text-align: justify;line-height: 2;box-sizing: border-box;"><p style="white-space: normal;box-sizing: border-box;"><span style="color: rgb(0, 0, 0);box-sizing: border-box;">参考文献</span><br style="box-sizing: border-box;"></p></section></section></section><section style="display: inline-block;width: 100%;vertical-align: top;box-sizing: border-box;" powered-by="xiumi.us"><section style="text-align: left;justify-content: flex-start;box-sizing: border-box;" powered-by="xiumi.us"><section style="display: inline-block;width: 66px;height: 4px;vertical-align: top;overflow: hidden;background-color: rgb(0, 0, 0);box-sizing: border-box;"><section style="text-align: justify;box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"><br style="box-sizing: border-box;"></p></section></section></section></section></section></section><section style="text-align: center;width: 100%;margin-right: 0%;margin-left: 0%;box-sizing: border-box;" powered-by="xiumi.us"><section style="display: inline-block;width: 92%;height: 110px;vertical-align: top;overflow-y: auto;box-sizing: border-box;"><section style="overflow-x: hidden;box-sizing: border-box;"><section style="text-align: justify;font-size: 12px;color: rgb(102, 102, 102);box-sizing: border-box;" powered-by="xiumi.us"><p style="white-space: normal;box-sizing: border-box;"> Chen M., Zhou S.Y., Fabriaga E.,etc.Food-drug interactions precipitated by fruit juices other than grapefruit juice: An update review.Food Drug Anal,2018 Apr,26(2S):61-71.</p><p style="white-space: normal;box-sizing: border-box;"> Ainslie G.R., Wolf K.K., Li Y.,etc.Assessment of a candidate marker constituent predictive of a dietary substance-drug interaction: case study with grapefruit juice and CYP3A4 drug substrates.Pharmacol Exp Ther,2014 Dec,351(3):576-584.</p><p style="white-space: normal;box-sizing: border-box;"> Sridharan K., Sivaramakrishnan G..Interaction of Citrus Juices with Cyclosporine: Systematic Review and Meta-Analysis.Eur J Drug Metab Pharmacokinet,2016 Dec,41(6):665-673.</p><p style="white-space: normal;box-sizing: border-box;">&nbsp;Maria G. Tanzi, PharmD. Juice interactions: What patients need to know . Pharmacy Today. 2013. Available from: https://www.pharmacytoday.org/article/S1042-0991(15)31392-X/fulltext#relatedArticles</p></section></section></section></section></section>
         

麻辣鸡翅 发表于 2022-8-8 10:42:58

都没吃过西柚

漂浮 发表于 2022-8-8 11:03:41

一天天发的也不知真假

忠志哥哥 发表于 2022-8-8 11:34:09

我不太信这些，想吃就吃

冀苍鸾 发表于 2022-8-8 11:50:14

超爱这种水果的

[太阳]Mr.Ζ 发表于 2022-8-8 12:36:58

也很少吃这种水果

小妖花满楼满fx 发表于 2022-8-8 15:59:12

西柚这么多门道

公路美学 发表于 2022-8-8 16:41:51

这个有点险

初一 发表于 2022-8-8 20:23:19

好的，知道了

流氓的愛妳不懂 发表于 2022-8-8 20:31:49

还有这种说法

云霓 发表于 2022-8-8 21:13:27

原来是这样啊

凝固 发表于 2022-8-8 22:16:36

小时候吃过西柚味的糖，贼难吃

曾曾 发表于 2023-4-20 20:53:47

好的，知道了

腼腆的旋转芜箐 发表于 2024-2-20 09:20:53

很少吃这个

鬼脸天晴 发表于 2024-2-20 09:35:19

谢谢楼主分享
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